How much is a ticket from Panama City to Santo Domingo La Isabela?

Flight prices from Panama City to Santo Domingo change depending on demand and time of booking.

Select your dates to check current offers.

Flying at off-peak hours — such as early morning or late evening — can help you save. Also, the best deals tend to appear in the weeks leading up to departure.

What are the airport options between Panama City and Santo Domingo?

If both departure and destination cities offer multiple airports, comparing them can help you save time and money.

• Airports in Panama City: Panama City has 2 airports - Pacífico International Airport, Paitilla.
• Airports in Santo Domingo: Santo Domingo has one airport operating, Santo Domingo - La Isabela.

Some airports have different terminals for low-cost and traditional airlines — knowing in advance can save time. You can filter results to see only the airports that suit you.

Adjust your flight filters for Panama City – Santo Domingo La Isabela

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Other popular destinations

Planning a trip to Dominican Republic? These cities are popular too: La Romana, Puerto Plata, Punta Cana, Santiago, Santo Domingo.

Sorting options let you see the most affordable flights first. Some results may include extra fees shown only at checkout — always read carefully to see what’s included.